                         SEQUENCE LISTING

<110>  Medical Research Council
       Matthews, David
       Barlow, Jillian
       McKenzie, Andrew
 
<120>  Antibodies Against IL-25

<130>  4433.1001002

<150>  US 61/101,293
<151>  2008-09-30

<150>  GB 0817891.5
<151>  2008-09-30

<160>  41    

<170>  PatentIn version 3.3

<210>  1
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Humanised VH domain

<220>
<221>  VARIANT
<222>  (30)..(30)
<223>  Xaa is Ser or Thr

<220>
<221>  VARIANT
<222>  (31)..(31)
<223>  Xaa is Gly, Asp, Ala, Ser, Val, Asn, Lys, Tyr or Met

<220>
<221>  VARIANT
<222>  (48)..(48)
<223>  Xaa is Met or Ile

<220>
<221>  VARIANT
<222>  (72)..(72)
<223>  Xaa is Val or Arg

<220>
<221>  VARIANT
<222>  (100)..(100)
<223>  Xaa is Asp, Asn or Gly

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Xaa Xaa Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Xaa 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Xaa Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Xaa Tyr Asp Gly Tyr Leu Tyr Phe Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  2
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Humanised VH domain RH2.5_S30T

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Asp Gly Tyr Leu Tyr Phe Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  3
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Humanised VH domain RH2.5_R71V

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Asn Ser Leu Arg Glu Asp Thr Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Asp Tyr Asp Gly Tyr Leu Tyr Phe Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Val Ser Ser 
        115                 120 


<210>  4
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Humanised VH domain RH2

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Asp Gly Tyr Leu Tyr Phe Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  5
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Humanised VH domain

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Asp Gly Tyr Leu Tyr Phe Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  6
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Humanised VH domain

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Asp Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Asp Gly Tyr Leu Tyr Phe Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  7
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Humanised VH domain

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Asp Gly Tyr Leu Tyr Phe Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  8
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Humanised VH domain

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Asp Gly Tyr Leu Tyr Phe Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  9
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Humanised VH domain

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Asp Gly Tyr Leu Tyr Phe Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  10
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Humanised VH domain

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Asp Gly Tyr Leu Tyr Phe Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  11
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Humanised VH domain

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Asp Gly Tyr Leu Tyr Phe Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  12
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Humanised VH domain

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Asp Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Asp Gly Tyr Leu Tyr Phe Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  13
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Humanised VH domain

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Asp Gly Tyr Leu Tyr Phe Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  14
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Humanised VH domain

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Asp Gly Tyr Leu Tyr Phe Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  15
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  15

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Ala Asp Gly Thr Val Glu Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  16
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  16
gacatccaga tgacccagac cacctccagc ctgagcgcca gcctgggcga ccgggtgacc     60

atcagctgca gcgcctccca gggcatcagc aactacctga actggtatca gcagaaggcc    120

gacggcaccg tcgagctgct gatctactac accagcagcc tgcacagcgg cgtgcccagc    180

cggtttagcg gcagcggctc cggcaccgac tacagcctga ccatctccaa cctggaaccc    240

gaggatatcg ccacctacta ctgccagcag tacagcaagc tgccctacac ctttggcggc    300

ggaacaaagc tggaaatcaa g                                              321


<210>  17
<211>  139
<212>  PRT
<213>  Mus musculus

<400>  17

Met Val Leu Ser Leu Leu Tyr Leu Leu Thr Ala Leu Pro Gly Ile Leu 
1               5                   10                  15      


Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
            20                  25                  30          


Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp 
        35                  40                  45              


Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp 
    50                  55                  60                  


Ile Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Asn 
65                  70                  75                  80  


Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
                85                  90                  95      


Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
            100                 105                 110         


Cys Ala Arg Glu Gly Tyr Asp Gly Tyr Leu Tyr Phe Ala Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 


<210>  18
<211>  417
<212>  DNA
<213>  Mus musculus

<400>  18
atggtgctgt ccctgctgta cctgctgacc gccctgcccg gcatcctgag cgaggtgcag     60

ctgcagcaga gcggccctga gctggtgaag cctggcgcca gcatgaagat cagctgcaag    120

gccagcggct acagcttcac cgactacacc atgaactggg tgaagcagag ccacggcaag    180

aacctggaat ggatcggcct gatcaacccc tacaacggcg gcaccagcta caaccagaac    240

ttcaagggca aggccaccct gaccgtggac aagagcagca gcaccgccta catggaactg    300

ctgtctctga ccagcgagga cagcgccgtg tactactgcg ccagagaggg ctacgacggc    360

tacctgtact tcgccatgga ctactggggc cagggcacca gcgtgaccgt gagcagc       417


<210>  19
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  19

Leu Leu Leu Ala Val Leu Gln Gly Val Cys Ala Glu Val Arg Leu Val 
1               5                   10                  15      


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser 
            20                  25                  30          


Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Asn Trp Ile Gly Trp Val 
        35                  40                  45              


Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile Gly Ile Ile Phe Pro 
    50                  55                  60                  


Gly Asp Ser Asp Thr Ile Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr 
65                  70                  75                  80  


Ile Ser Val Asp Lys Ser Ile Asn Thr Ala Tyr Leu Gln Trp Ser Ser 
                85                  90                  95      


Leu Lys Ala Thr Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Asn Pro 
            100                 105                 110         


Pro Glu Tyr Ser Gly Ala Tyr His Asp Gly Trp Phe Asp Pro Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Ile Val Ser Ser 
    130                 135         


<210>  20
<211>  411
<212>  DNA
<213>  Homo sapiens

<400>  20
ctcctcctgg ctgttctcca aggagtctgt gccgaggtgc gccttgtgca gtctggagca     60

gaggtgaaaa agccggggga gtctctgaag atctcctgta aggcttctgg atacagtttt    120

accagtaact ggatcggctg ggtgcgccag atgcccggga aaggcctgga gtggattggg    180

atcatctttc ctggtgactc tgataccata tacagcccgt ccttccaagg ccaggtcacc    240

atttcagtcg acaagtccat caataccgcc tacctgcagt ggagcagcct gaaggccacg    300

gacaccgcca tgtattactg tgcgagacag aacccccccg agtatagtgg cgcatatcat    360

gatgggtggt tcgacccctg gggccaggga accctggtca tcgtctcctc a             411


<210>  21
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: RHA VH domain

<400>  21

Met Gly Ser Thr Ala Ile Leu Gly Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Val Cys Ala Glu Val Arg Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Thr Met Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn 
65                  70                  75                  80  


Gln Asn Phe Lys Gly Gln Val Thr Ile Ser Val Asp Lys Ser Ile Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Thr Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Gly Tyr Asp Gly Tyr Leu Tyr Phe Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Ile Val Ser Ser 
    130                 135                 140     


<210>  22
<211>  424
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Nucleic acid encoding RHA VH domain

<400>  22
atggggtcaa ccgccatcct tggcctcctc ctggctgttc tccaaggagt ctgtgccgaa     60

gtgcgccttg tgcagtctgg agcagaagtg aaaaagccgg gggagtctct gaagatctct    120

tgcaaggctt ctggatacag ttttaccgac tacaccatga actgggtgcg ccagatgccc    180

gggaaaggcc tggagtggat tgggcttatt aatccttaca atggtggtac tagctacaac    240

cagaatttca agggccaagt caccatttca gtcgacaagt ccatcaatac cgcctacctg    300

cagtggagca gcctgaaggc cacggacacc gccatgtatt actgtgcgag agagggctat    360

gatggttacc tttactttgc tatggactac tggggccagg gaaccctggt catcgtctcc    420

tcag                                                                 424


<210>  23
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Ser Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn 
            100                 105                 110         


Ser Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  24
<211>  381
<212>  DNA
<213>  Homo sapiens

<400>  24
atgagggtcc ctgctcagct cctgggactc ctgctgctct ggctcccaga taccagatgt     60

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc    120

atcacttgcc gggcgagtca gggcattagc aattatttag cctggtatca gcagaaacca    180

gggaaagttc ctaaactcct gatctatgct gcatccactt tgcaatcagg ggtcccatct    240

cggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct    300

gaagatgttg caacttatta ctgtcaaaag tataacagtg ccccgtacac ttttggccag    360

gggaccaagc tggagatcaa a                                              381


<210>  25
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Humanised 2c3 VK domain RKA

<400>  25

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Gly 
        35                  40                  45              


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser 
            100                 105                 110         


Lys Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  26
<211>  381
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Nucleic acid encoding humanised 2c3 VK domain
       RKA

<400>  26
atgagggtcc ctgctcagct cctgggactc ctgctgctct ggctcccaga taccagatgt     60

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc    120

atcacttgca gtgcatccca gggcattagc aattatctga attggtatca gcagaaacca    180

gggaaagttc ctaaactcct gatctattac acatcaagtt tacactcagg ggtcccatct    240

cggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct    300

gaagatgttg caacttatta ctgtcagcag tatagcaagc tgccgtacac gtttggccag    360

gggaccaagc tggagatcaa a                                              381


<210>  27
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Ser Tyr 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Gly Gly Thr Gly Phe Thr Lys Tyr Ser Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Tyr Asn Asn Tyr Ala Ala Glu Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  28
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  28
gaggtgcagc tggtggagtc tggggctgag gtgaagaagc ctggggcctc agtgaaagtt     60

tcgtgcaagg cttctggata ctccttcagt agttatggta tacattgggt gcgccaggcc    120

cccggacaaa ggcttgagtg gatgggatgg atcaacggtg gcactggttt tacaaaatat    180

tcacagaatt ttcagggcag agtcacccta accagggaca cttccgcgag cacagcctac    240

ttggaactga acagcctgag atctgaagac acgggtgtat attactgtgc gagggatccc    300

tacaataact acgcggcgga acttgactac tggggccagg gaaccctggt caccgtctcc    360

tca                                                                  363


<210>  29
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  29

Ser Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  30
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  30

Tyr Thr Ser Ser Leu His Ser 
1               5           


<210>  31
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  31

Gln Gln Tyr Ser Lys Leu Pro Tyr Thr 
1               5                   


<210>  32
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  32

Asp Tyr Thr Met Asn 
1               5   


<210>  33
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  33

Glu Gly Tyr Asp Gly Tyr Leu Tyr Phe Ala Met Asp Tyr 
1               5                   10              


<210>  34
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Heavy Chain CDR1

<400>  34

Gly Tyr Thr Met Asn 
1               5   


<210>  35
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  35

Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  36
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Heavy Chain CDR3

<400>  36

Glu Asp Tyr Asp Gly Tyr Leu Tyr Phe Ala Met Asp Tyr 
1               5                   10              


<210>  37
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Gly Ser Thr Ala Ile Leu Gly Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Val Cys Ala 
            


<210>  38
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  38

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Arg Cys 
            20  


<210>  39
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Asp Thr Arg Cys 
            20          


<210>  40
<211>  423
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Nucleic acid encoding RH2.5 R71V

<400>  40
atgggcagca cagccattct gggcctgctg ctggccgtgc tgcagggcgt gtgcgccgag     60

gtgcagctgg tcgagagcgg agccgaggtg aagaagccag gcgccagcgt caaggtgtcc    120

tgcaaggcca gcggctacag cttctccggc tacaccatga actgggtgcg gcaggcccca    180

ggccagaggc tggaatggat gggcctgatc aacccctaca acggcggcac cagctacaac    240

cagaacttca agggcagggt gacactgacc gtggatacca gcgccagcac cgcctacctg    300

gaactgaaca gcctgagaag cgaggacacc ggcgtgtact actgcgccag agaggactac    360

gacggctacc tgtacttcgc catggactac tggggccagg gcaccctggt gaccgtgagc    420

agc                                                                  423


<210>  41
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Kozak consensus sequence

<400>  41
aagcttgccg ccacc                                                      15

